Innenrücktitelbild: Photoswitchable PROTACs for Reversible and Spatiotemporal Regulation of NAMPT and NAD⁺ (Angew. Chem. 12/2024)

Reversible and spatiotemporal regulation of protein degradation is important for chemical biology and drug discovery. In their Research Article (e202315997), Guoqiang Dong, Chunquan Sheng et al. developed activator-based photoswitchable proteolysis-targeting chimera (PS-PROTAC) for the optical control of NAMPT and NAD+ both in vitro and in vivo.