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March 5, 2024iScienceOpen Access

Mathematical model calibrated to in vitro data predicts mechanisms of antiviral action of the influenza defective interfering particle “OP7”

Daniel Rüdiger Julita Piasecka Jan Küchler Carolina Nobre Ribeiro Pontes Tanja Laske Sascha Young Kupke Udo Reichl

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Abstract

Defective interfering particles (DIPs) are regarded as potent broad-spectrum antivirals. We developed a mathematical model that describes intracellular co-infection dynamics of influenza standard virus (STV) and "OP7", a new type of influenza DIP discovered recently. Based on experimental data from

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Rüdiger et al. (2024) studied this question.

synapsesocial.com/papers/68e75a06b6db6435876d1323 https://doi.org/10.1016/j.isci.2024.109421

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