952 A conservative treatment of CIN 2 using a coriolus versicolor-based vaginal gel: an observational study

Introduction/Background According to the American Society of Colposcopy and Cervical Pathology (ASCCP), 50% of CIN 2 cases managed conservatively spontaneously regress. The aim of this study was to evaluate the effect of a Coriolus versicolor-based vaginal gel in the conservative management of CIN 2 lesions. Methodology A retrospective and prospective cohort, single-center, observational study, including women aged ≥18 years with a diagnosis of CIN 2. Inclusion criteria aligned with the Spanish Society of Colposcopy and Cervical Pathology (AEPCC) guidelines for CIN 2 conservative treatment, requiring visible transition zone in colposcopy images, lesions affecting less than 2 quadrants, non-affected endocervix, and accepting cytology/colposcopy after 6 months. The retrospective cohort, spanning 2010 to 2017, assessed the regression, persistence, and progression of HPV-dependent lesions in women with CIN 2 undergoing conservative management. Conversely, women in the prospective cohort received treatment with a Coriolus versicolor-based vaginal gel—1 cannula/day for the first month, followed by 1 cannula every other day for the subsequent 5 months. Baseline and 6-month biopsies were performed for evaluation. Results In the retrospective cohort, 117 women (average age: 35.91) were included, while the prospective cohort included 44 women (average age: 36.09). Three patients from the prospective cohort were excluded due to the absence of a biopsy after 6 months. Following a 6-month treatment, 68.2% in the treated group showed regression, 11.4% persisted in CIN 2, and 18.2% progressed to CIN 3. In the retrospective cohort, 55% regressed, 13% persisted, and 32% progressed. However, non statistically significant differences were observed. Conclusion The Coriolus versicolor-based vaginal gel 6-month treatment seems to increase the regression of the lesions compared to spontaneous resolution and could represent a clinical advantage compared to the 'wait and see' approach in patients meeting the conservative treatment criteria for CIN 2 lesions. Disclosures .