362 OPTIMUS: optimising cardiovascular health in endometrial cancer survivors- the impact on quality of life and barriers to change

Introduction/Background Addressing quality of life (QoL) in the growing population of endometrial cancer survivors is crucial. Cardiovascular risk factors play a pivotal role in survivorship, influencing QoL and long-term outcomes. This study aimed to identify determinants of QoL, barriers to implementing lifestyle changes, and assess the impact of optimising cardiovascular risk factors. Methodology A prospective cohort study integrated cardiovascular risk assessments into routine follow-up over 12 months. These informed the tailored lifestyle and pharmacotherapy advice women received. QoL was measured using SF-36 and QLACS. Predictor variables were identified using Kruskal-Wallis tests with Dunn-Bonferroni correction. Regression analyses examined the relationships. Changes in QoL were evaluated using paired t-tests and Wilcoxon-signed-ranks-tests. Semi-structured interviews were conducted to identify barriers to change. Results At baseline, 70 women completed QoL questionnaires. Age and BMI negatively impacted physical functioning (median (IQR) score <50 years: 87.5 (40.0–100.0)%, vs. ≥70 years: 50.0 (30–72.5)%, p=0.03; BMI 18.5–24.9kg/m2: 95.0 (80.0–100.0)%, vs. ≥30.0kg/m2: 60.0 (35.0–85.0)%, p=0.001). Socioeconomic deprivation and ethnicity influenced QoL; Asian women had significantly poorer physical and social functioning and lower QoL compared to White women (χ2=6.18, p=0.01). Age, BMI, ethnicity and socioeconomic status were independent predictors of physical functioning (R2 0.46, p<0.0001). Optimising cardiovascular risk factors resulted in weight loss (-5.4kg, p<0.0001), improvement in QRISK3 score (-2.3%, p=0.03), a significant improvement in general QoL (mean (SD) SF-36 general health score baseline: 58.8 (17.7)%, vs. 12-month: 66.8 (14.7)%, p<0.05) and physical functioning (median (IQR) score, baseline: 75.0 (40.0–90.0)%, vs. 12-month: 85.0 (65.0–100.0)%; p=0.02). Barriers to lifestyle changes included time, cost, and lack of individualised dietary advice. Conclusion Ethnicity and socioeconomic deprivation are important determinants of QoL in endometrial cancer survivors. Targeting risk factors during survivorship positively influences QoL and cardiovascular health. Addressing barriers to lifestyle changes, with consideration of diverse backgrounds and socioeconomic contexts, is a crucial step toward equality in survivorship. Disclosures HJA None SJK None LS: None DB: None MKR Eli Lilly, GSK EJC None