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It is known that, compared with normal cells, cancer cells are characterized by an intensification of glycolysis and an increase in glucose uptake to ensure high proliferative activity. Meanwhile, the question of the relationship between the intensity of glycolysis and the metastatic potential of tumor cells remains open. The aim of the study was to determine the rate of glucose uptake (GCR) and lactate production (LPR) by Lewis lung carcinoma cells with high (LLC) and low metastatic potential (LLC/R9) during 1-day growth in vitro under standard incubation conditions. The results showed that glycolysis intensity was significantly higher in low-metastatic Lewis lung carcinoma cells compared to the high-metastatic cells.
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Hnatiuk et al. (2024) studied this question.
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