Antioxidant effects and ex vivo/in vitro mass reduction of calcium oxalate urinary stones of several extracts from Paronychia argentea L

Our study focused on the evaluation of the antioxidant and antilithiasis activity of Paronychia argentea L. extracts used in traditional medecine to treat or prevent urolithiasis, particularly their ability to dissolve natural oxalocalcic stones from a human. Aerial parts of the Paronychia argentea L. plant were extracted by two distinct methods, using five solvents of varying polarities. They were identified by assays of total polyphenols and flavonoids. Antioxidant activity was assessed using five different methods, while evaluation antilithiasis activity was carried out through three distinct approaches. The herb Paronichia argentea L possesses antilithiasis and antioxidant properties that could be beneficial in treating urinary stone disease by reducing their size, achieving a rate of 52%.