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February 29, 2024Journal of VirologyOpen Access

The SARS-CoV-2 Spike is a virulence determinant and plays a major role on the attenuated phenotype of Omicron virus in a feline model of infection

Mathias Martins Mohammed Nooruzzaman Jessie Lee Cunningham Chengjin Ye Leonardo C. Caserta Nathaniel Jackson Luis Martínez‐Sobrido Yīng Fāng Diego G. Diel

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Abstract

The role of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.1 Spike (S) on disease pathogenesis was investigated. For this, we generated recombinant viruses harboring the S D614G mutation (rWA1-D614G) and the Omicron BA.1 S gene (rWA1-Omi-S) in the backbone of the ancestral SARS-CoV-2 WA1 strain genome. The recombinant viruses were characterized

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Martins et al. (2024) studied this question.

synapsesocial.com/papers/68e76e44b6db6435876e3457 https://doi.org/10.1128/jvi.01902-23

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