Rücktitelbild: Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine (Angew. Chem. 14/2024)

A rapid functional group transformation method that converts metabolic carboxylic acids into a new ketone within 10 minutes using the reagent 4-nitrophenyl-2H-azirine (the bait for the fish) has been developed by Daniel Globisch et al. in their Communication (e202318579). The newly formed ketone was then captured by the chemical probe methodology Quant-SCHEMA (the fishing device) for quantification of all carboxylic acids even at very low quantities (depth of the ocean). This bifunctional methodology represents a new chemical biology tool for biomarker discovery and metabolomics.