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Background: Bromelain is a complex of plant-derived proteolytic enzymes found in almost all parts of the Pineapple plant (Ananas comosus L.Merr.) and is currently used in treating muscle-skeletal disorders.Objectives: This study aimed to develop natural and modified Bromelain gels for potentially treating muscle-skeletal disorders and assessing their physical-chemical properties.Natural Bromelain and its chemically altered form, modified with dextran aldehyde, were used as active ingredients.Methods: Investigation of physical and chemical properties of gels, identification of gels by Fourier transform infrared (FT-IR) spectroscopy.Results: The proteolytic activity of the gels for 15 months is stable and remains 85-93% compared to the initial activity.Conclusions: The spreadability, consistency, pH, thermal, and colloidal stability of the base and gels containing natural and modified Bromelain were satisfactory.
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Nadirashvili et al. (2024) studied this question.
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