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Introduction: The ABO is still the most important blood group system in transfusion and transplantation therapy. ABH antigens are the product of gene combinations at three different loci (ABO, Hh, and Se) and produce certain glycosyltransferases for oligosaccharide precursor chain with monosaccharides at specified linkages, where the terminal sugar influences antigen specificity. Exons 6 and 7 are the longest coding region providing the catalytic domain for the ABO glycosyltransferases. The substitution of amino acid within exons 6 and 7 coding regions of ABO glycosyltransferases is responsible for ABO groups/ subgroups determination.
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Osman et al. (2024) studied this question.
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