Pt-Pt interactions are able to fold a flexible dinucleotide chain, promoting nucleobase stacking. In their Research Article, M. Gómez-Gallego, M. A. Sierra, and co-workers report the molecular structures of cyclometallated PtII purine dinucleotides as chiral helices sustained by Pt−Pt intramolecular interactions. These interactions force the purine nucleobases to stand parallel, as parallel are the four towers of Madrid city, in which the reported compounds have been made. The Pt−Pt interactions can be detected in solution by the appearance of the characteristic MMLCT transitions in the UV/Vis spectra. The authors would like to thank Pablo García-Álvarez for creating the cover artwork.
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Lorenzo‐Aparicio et al. (2024) studied this question.
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