Loss of appetite, weakness and chronic fatigue: current approach

Fatigue and chronic fatigue are frequently encountered complaints in clinical practice, and their etiology is difficult to determine. In addition to increasing patient dissatisfaction due to the lack of clarification of the etiology, it brings about a significant increase in cost due to the fact that patients consult multiple physicians. In this review, current clinical practices, including especially overlooked points in the etiology of weakness and fatigue, investigations that should be planned, diagnosis, treatment, and lifestyle recommendations, are reviewed.