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February 28, 2024Communications BiologyOpen Access

Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALS

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LTLouise ThiryJSJulien SiroisTDThomas M. Durcan

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Thiry et al. (2024) studied this question.

synapsesocial.com/papers/68e77206b6db6435876e6d0chttps://doi.org/10.1038/s42003-024-05925-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hypoimmunogenic human motor neurons induced from iPSCs in vivo substantially ameliorate ALS disease in large animal models2025
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  3. 3Scalable, optically-responsive human neuromuscular junction model reveals convergent mechanisms of synaptic dysfunction in familial ALS2024 · 1 citations
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  5. 5Aberrant evoked calcium signaling and nAChR cluster morphology in a SOD1 D90A hiPSC-derived neuromuscular model2024 · 3 citations