⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

February 28, 2024Journal of Medicinal Chemistry

Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[d]thiazole Structural Motif for the Treatment of Inflammatory Bowel Disease (IBD)

Ruoqing Zeng Meimiao Fang Ancheng Shen Xiaolei Chai Yumiao Zhao Mingyao Liu Lingfeng Zhu Weiwei Rui Bo Feng Liang Hong Chunyong Ding Zilan Song Weiqiang Lü Ao Zhang

View at Publisher

Ask AI

Bookmark

Share

Abstract

Accumulating evidence has demonstrated a critical pathological role of oxysterol receptor GPR183 in various inflammatory and autoimmune diseases, including inflammatory bowel disease (IBD). However, the currently reported GPR183 antagonists are very limited and not qualified for

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Zeng et al. (2024) studied this question.

synapsesocial.com/papers/68e77226b6db6435876e7881 https://doi.org/10.1021/acs.jmedchem.3c01905

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Development of Potent G Protein Pathway-Biased GPR183 AgonistsOriginal Research · 2026
2Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative ColitisOriginal Research · 2022 · 30 citations
3Development of G Protein-Coupled Receptor 183 Benzimidazole Antagonists Utilizing a Core-Hopping ApproachOriginal Research · 2026
4Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease2024 · 8 citations
5Discovery of Novel Selective Dual Agonists Targeting S1PR1 and S1PR5 for the Treatment of Inflammatory Bowel DiseaseIn Vitro Study · 2026 · 2 citations

More related papers

Discovery of a Series of 4-Amide-thiophene-2-carboxyl Derivatives as Highly Potent P2Y<sub>14</sub> Receptor Antagonists for Inflammatory Bowel Disease Treatment2024
Discovery of Non-prostanoid EP4 Agonists for the Treatment of Inflammatory Bowel Disease2026
Discovery of Benzofuran-2-Carboxylic Acid Derivatives as Potent PTPRO Inhibitors with Oral Efficacy for Treatment of Inflammatory Bowel Disease2026

More from Journal of Medicinal Chemistry

Salicylamides as RNA-Dependent RNA Polymerase Inhibitors with Antiviral Activity against West Nile and Zika VirusesMon,
Chemical Determinants of Spinal Analgesia in NTS2-Selective MacrocyclesMon,