Selective serotonin reuptake inhibitors (SSRI) are commonly used for the treatment of depression and anxiety. Inhibition of serotonin reuptake in platelets increases bleeding risk in patients taking SSRIs. Here, we present the case of a 52-year-old patient who developed severe postsurgical bleeding requiring blood transfusion following panniculectomy. SSRI-induced bleeding is dose-related and strongly influenced by individual variations in drug metabolizing enzymes and transporters.
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Rogers et al. (2024) studied this question.
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