FIGURE 1 from INHBA is Enriched in HPV-negative Oropharyngeal Squamous Cell Carcinoma and Promotes Cancer Progression

GSEA identifying INHBA as a leading driver of EMT in HPV-negative tumors. A, Dot plot of pathways enriched and depleted in HPV-negative compared with HPV-positive OPSCC tumor as determined by GSEA of transcriptomes from n = 62 primary tumor samples (Ulm cohort). Results were ranked according to the NES, dots were colored according to FDR and size was determined by the number of genes. B, GSEA plot of the top pathway (EMT) showing enrichment score (green curve), position of genes (black lines) with the leading edge (p-EMT), NES, and FDR. C, Volcano plot showing the log₂ fold change of genes upregulated in HPV-positive (red) and HPV-negative OPSCC (blue), with INHBA (red circle) as the highest upregulated leading edge in HPV-negative tumors.