FIGURE 5 from Inhibition of Aurora Kinase Induces Endogenous Retroelements to Induce a Type I/III IFN Response via RIG-I

Induction of endogenous retroviruses by Aurora kinase inhibitors and screen hit drugs. A, TPM heat maps for all significant TEs, Padj < 0.05 in at least one condition after 5 days treatment with the indicated drugs as described in Fig. 3A. B, TPM heat maps for all significant TEs, Padj < 0.05 in at least one condition in MAVS KO or control clones after 5 days alisertib treatment. C, Synergistic interaction between AURKi and DNTMi for IFN induction. HCT116-IFI27 cells were treated for 5 days with the indicated doses of alisertib and/or decitabine, then reporter luciferase activity was measured. D, No synergy between AURKi and irinotecan. As in C but with irinotecan instead of decitabine.