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February 23, 2024LifeOpen Access

Structural and Dynamic Analyses of Pathogenic Variants in PIK3R1 Reveal a Shared Mechanism Associated among Cancer, Undergrowth, and Overgrowth Syndromes

Nikita R. Dsouza Catherine E. Cottrell Olivia M. T. Davies Megha M. Tollefson Ilona J. Frieden Donald Basel Raúl Urrutia Beth A. Drolet Michael T. Zimmermann

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Abstract

The PI3K enzymes modify phospholipids to regulate cell growth and differentiation. Somatic variants in PI3K are recurrent in cancer and drive a proliferative phenotype. Somatic mosaicism of

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Dsouza et al. (2024) studied this question.

synapsesocial.com/papers/68e77de8b6db6435876f17ec https://doi.org/10.3390/life14030297

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