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Abstract Wed077: The role of senescence in HFpEF induced by cardiometabolic syndrome

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This study demonstrates that senescence is linked to HFpEF in mice with cardiometabolic syndrome, indicating potential therapeutic insights.

HFpEF phenotypes improved significantly after genetic senolytic therapy in mice exposed to multiple comorbidities.
The 4-Hit mouse model showed approximately 50% increase in left ventricular mass despite stable ejection fraction.
Senolytic treatment reduced macrophage infiltration in the hearts of mice with cardiometabolic stress.
Analysis revealed significant pathways affected by senescence, including mitochondrial dysfunction and inflammation.

Dai et al. (2025) studied this question.

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View Full Paper

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Authors

This study demonstrates that senescence is linked to HFpEF in mice with cardiometabolic syndrome, indicating potential therapeutic insights.

HFpEF phenotypes improved significantly after genetic senolytic therapy in mice exposed to multiple comorbidities.
The 4-Hit mouse model showed approximately 50% increase in left ventricular mass despite stable ejection fraction.
Senolytic treatment reduced macrophage infiltration in the hearts of mice with cardiometabolic stress.
Analysis revealed significant pathways affected by senescence, including mitochondrial dysfunction and inflammation.

Dai et al. (2025) studied this question.

View Full Paper

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Bookmark