TABLE 1 from Estrogen Receptor Mutations as Novel Targets for Immunotherapy in Metastatic Estrogen Receptor–positive Breast Cancer

Jonathan Goldberg; Na Qiao; Jennifer L. Guerriero; Brett Gross; Yagiz Meneksedag; Yoshimi F. Lu; Anne V. Philips; Tasnim Rahman; Funda Meric‐Bernstam; Jason Roszik; Ken Chen; Rinath Jeselsohn; Sara M. Tolaney; George E. Peoples; Gheath Alatrash; Elizabeth A. Mittendorf

doi:10.1158/2767-9764.25266537

February 22, 2024Open Access

TABLE 1 from Estrogen Receptor Mutations as Novel Targets for Immunotherapy in Metastatic Estrogen Receptor–positive Breast Cancer

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Key Points

Candidate ESR1-derived peptides emerge as potential targets for immunotherapy, presenting novel opportunities to treat metastatic breast cancer carrying defined mutations.
Specific estrogen receptor mutations generate tumor-specific peptide sequences, establishing molecular targets for directed cellular therapies against refractory disease.
Screening of recurrent estrogen receptor alterations identifies candidate epitopes, supporting further translational validation for tailored breast cancer vaccines.

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Implication

Preclinical analysis identifies candidate ESR1-derived peptides in metastatic breast cancer, highlighting novel targets for mutation-directed immunotherapy.

Abstract

Identification of candidate ESR1-derived peptides

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Cite This Study

Goldberg et al. (2024) studied this question.

synapsesocial.com/papers/68e781eeb6db6435876f4eca https://doi.org/10.1158/2767-9764.25266537

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TABLE 1 from Estrogen Receptor Mutations as Novel Targets for Immunotherapy in Metastatic Estrogen Receptor–positive Breast Cancer

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

TABLE 1 from Estrogen Receptor Mutations as Novel Targets for Immunotherapy in Metastatic Estrogen Receptor–positive Breast Cancer

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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