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February 21, 2024Physical BiologyOpen Access

Coupled action potential and calcium dynamics underlie robust spontaneous firing in dopaminergic neurons

Hadeel Khamis O. Cohen

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Abstract

Dopaminergic neurons are specialized cells in the substantia nigra, tasked with dopamine secretion. This secretion relies on intracellular calcium signaling coupled to neuronal electrical activity. These neurons are known to display spontaneous calcium oscillations

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Cite This Study

Khamis et al. (2024) studied this question.

synapsesocial.com/papers/68e78447b6db6435876f6ce0 https://doi.org/10.1088/1478-3975/ad2bd4

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The control of firing pattern in nigral dopamine neurons: burst firingOriginal Research · 1984 · 1,346 citations
2Control of firing patterns through modulation of axon initial segment T‐type calcium channelsOriginal Research · 2011 · 61 citations
3Spontaneous Activity of Isolated Dopaminergic Periglomerular Cells of the Main Olfactory BulbOriginal Research · 2005 · 56 citations
4Ionic currents influencing spontaneous firing and pacemaker frequency in dopamine neurons of the ventrolateral periaqueductal gray and dorsal raphe nucleus (vlPAG/DRN): A voltage-clamp and computational modelling studypreclinical · 2017 · 23 citations
5Dynamics of synchronous bursts in functionally coupled midbrain dopamine neurons driven by diverse excitatory inputsOriginal Research · 2026

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