NRF2 activity in human OSCC. TP53, CDKN2A, and NRF2 pathway mutational profiles from 268 HPV—oral cavity squamous cell carcinoma in TCGA. A, Waterfall plot—relative frequency and mutational classes. Color—mutational class. B, Kaplan–Meier plot—disease specific survival of the 254 patients with HPV—oral cavity squamous cell carcinoma with available outcomes data, stratified by NRF2 pathway alteration status. Red—Altered NRF2 pathway. Blue—wild-type NRF2 pathway. P value represents log-rank test. HR—hazard ratio with 95% confidence interval.
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Hamad et al. (2024) studied this question.
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