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Abstract This study investigated the solid-fluid and vapor-liquid equilibrium of binary {CO₂ + ketoprofen} and ternary {CO₂ + ethanol + ketoprofen} systems across various molar fractions. Experiments were conducted at 313 to 333 K and pressures up to 14 MPa, using a visual synthetic static method with a variable volume cell. The results showed increased ketoprofen solubility with temperature and minimal impact of ketoprofen on the ternary system's bubble pressure. Thermodynamic modeling employed the Redlich-Kwong-Peng-Robinson equation of state with quadratic mixing rules for fluid phases and a pure solid model for ketoprofen, accurately describing the observed phase behavior.
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Mattos et al. (2024) studied this question.
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