Matteson Homologation-Based Total Synthesis of Meliponamycin A

Dirk Trauner; Christoph Etling

doi:10.1055/s-0043-1773077

February 14, 2024SynfactsOpen Access

Matteson Homologation-Based Total Synthesis of Meliponamycin A

View Full Paper

Ask AI

Bookmark

Share

Key Points

Stereoselective total synthesis achieves construction of meliponamycin A, establishing a direct chemical pathway for this antimicrobial natural product.
Synthesis relies on iterative Matteson homologation to assemble the carbon backbone, enabling precise control over chiral centers within the structure.
This strategy highlights versatile assembly routes for peptide-polyketide hybrid natural products, supporting future medicinal chemistry investigations.

Implication

Total synthesis demonstrates stereoselective preparation of meliponamycin A via Matteson homologation, highlighting efficient routes to complex peptide-polyketide hybrid natural products.

Abstract

Key words total synthesis - antimicrobial natural products - peptide−polyketide hybrid natural product - stereoselective synthesis - Matteson homologation

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Trauner et al. (2024) studied this question.

synapsesocial.com/papers/68e79403b6db643587704afd https://doi.org/10.1055/s-0043-1773077

View Full Paper

Ask AI

Bookmark

Share

Matteson Homologation-Based Total Synthesis of Meliponamycin A

Key Points

Implication

Abstract

Discussion

Cite This Study

Matteson Homologation-Based Total Synthesis of Meliponamycin A

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading