Bisphenol A-A Major Concern For Ovarian Function: Protective Role Of Black Tea Extract

Bisphenol A, an endocrine disruptor and also an environmental toxicant which is correlated with adverse estrogenic effects in both humans and other environmental species. This study depicts the investigation of the disintegration in ovarian function caused by BPA and the ameliorative effects of black tea extract (BTE). Eight-week-old female Wistar rats were treated with BPA (10µg and 100 µg/kg body weight/day) for 14 days by oral gavage, and then supplemented with BTE (1ml/100gm body weight/day) for 14 days orally. The oxidative and antioxidative stress parameters were measured in the ovaries. In this study, elevated ovarian level of nitric oxide and were observed in malondialdehyde BPA exposed animals as compared to the control animals. Furthermore, BPA exposure resulted in marked reduction in the activities of antioxidant enzymes, superoxide dismutase and catalase. All of these BPA induced effects were overturned to good dimension by the oral supplementation of black tea extract.