Two undescribed furanones (1-2) were isolated from Coptis deltoidea rhizome.HRESIMS, NMR and ECD calculations were used to ascertain their structures.Based on the inflammation cell model of RAW264.7 macrophage which induced by lipopolysaccharides (LPS), RNA-Seq was used to reveal the biological activity of 1.According to the findings, 1 dramatically changed the genes expression profile of the inflammatory cell model produced by LPS in RAW264.7 cells which indicated that it had potential anti-inflammatory activitiy.
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Jiang et al. (2024) studied this question.
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