Possible Ameliorating Role of Selenium Nanoparticles versus Metformin Drug in Polycystic Ovary Syndrome Induced in Adult Albino Rat Model: A Histological, Immunohistochemical and Biochemical Study

Introduction: Through scientific literature, Polycystic ovary syndrome (PCOS) is a relatively common endocrine disorder among young women and leads to metabolic problems associated with the onset of infertility. Selenium nanoparticles (SeNps) is an essential trace element playing vital role in the physiological processes. It was ignored as a therapeutic agent in the past, but recently it was revealed that it must be obtained from diet as it cannot be produced by organisms.Aim of study: The present study might draw attention to the effective and promising role of Selenium nanoparticles (SeNps) in the treatment of PCOS as compared with the metformin.Materials and methods: Forty adult female rats were enrolled and randomly divided into four equal groups; control group received no manipulation, untreated PCOS group, metformin treated group and SeNps treated group. Animals were sacrificed and biochemical, molecular and histopathological analysis were performed.Results: Both metformin and SeNps succeeded in restoring normal follicular capacity of the affected ovaries with PCOS regarding ; the histological follicular restoration, hormonal and blood glucose level regulation, immunological and biochemical improvement . However, SeNps was more superior in enhanced the oxidative status enzymes, where it significantly reduced the elevated GPx and SOD tissue levels compared to metformin group, and decreased tissue inflammatory mediators TNF-alpha and IL-1 in the ovarian tissue.Conclusion: The extent of ovarian regeneration, excreted by selenium nanoparticles (SeNPs) not only comparable to that of metformin drug but also it has a great privilege as an alternative therapy of PCOS especially in intolerant patients to oral hypoglycemic drugs.