Abstract Background: Asthma is a chronic inflammatory disease of the respiratory tract that significantly impacts daily activities and quality of life. Asthma exercise is a nonpharmacological approach to asthma management. The effects of asthma exercise on interleukin-17 (IL-17) and indoleamine 2,3-dioxygenase (IDO) levels remains understudied. The effects of asthma exercise on IL-17 and IDO levels were investigated. Methods: This study included 39 participants with mild-to-moderate persistent asthma. Participants engaged in 60 minute of asthma exercise four times a week for 2 months. IL-17 and IDO levels were measured in peripheral blood mononuclear cells (PBMCs) stimulated with the house dust mite allergen Dermatophagoides pteronyssinus using ELISAs. Skin prick tests were conducted using Dermatophagoides pteronyssinus, Dermatophagoides farinae, and Blomia tropicalis. Results: IDO levels (p-value= 0.03) increased significantly and IL-17 levels decreased significantly (p-value= 0.004) after asthma exercise. However, no significant correlation was found between the decrease in IL-17 and the increase in IDO (p-value = 0.09). Conclusion: Exercise suppresses immune responses in atopic asthma induced by house dust mite allergens. Thus, exercise is a promising therapeutic approach for atopic asthma. The effects of exercise on IDO and IL-17 levels highlight the potential of exercise to alleviate asthma-related inflammation and airway hypersensitivity.Further research is needed to understand the underlying mechanisms and optimize asthma management strategies.
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Kusuma et al. (2024) studied this question.
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