Rücktitelbild: A Giant Heterometallic Polyoxometalate Nanocluster for Enhanced Brain‐Targeted Glioma Therapy (Angew. Chem. 10/2024)

Giant heterometallic polyoxometalate (POM) clusters own flexibly adjustable active sites and are promising functional drug carriers. In their Research Article (e202319700), Jiefei Wang, Bingyang Shi, Junwei Zhao et al. designed the largest (3.0 nm × 6.0 nm) Ce3+/Ag+ co-encapsulated POM cluster with blood brain barrier-traversing and mitochondrial targeting properties to solve the long-standing brain delivery problem of drugs for glioma. As the first brain-targeting POM drug, Ag+ specifically activates reactive oxygen species regulated apoptosis pathway of glioma and efficiently prolongs the survival of orthotopic glioma-bearing mice.