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In vitro analysis demonstrates cytotoxic activity of Acrostichum aureum ecdysteroids against human cancer cell lines, highlighting novel natural chemical candidates.
Chemical investigation of the EtOAc extract from the aerial parts of Acrostichum aureum distributed along coastlines of Vietnam lead to the isolation of a new ecdysteroid, named pterosterone 20,22-acetonide (1), along with twelve known compounds (2-13).Their structures were elucidated by spectroscopic methods including 1D, 2D NMR and HR-ESI-MS analysis as well as comparison with the results of previous studies.Five ecdysteroids (1-5) were evaluated for their cytotoxic activity against the LU-1, MCF7 and HepG2 human cancer cell lines using the SRB assay.Ecdysteroids 1 and 2 having a 20,22-dimethyl acetal group showed cytotoxicity against all tested cell lines with IC50 values in the range 51.59 to 60.14 μM.The other compounds were considered as inactive in this test.
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Minh et al. (2024) studied this question.
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