Analysis demonstrates that hMENA isoforms regulate tertiary lymphoid structure localization in lung cancer, highlighting their role in predicting immune checkpoint blockade response.
Tertiary Lymphoid Structures (TLS) correlate with positive outcomes in patients with NSCLC and the efficacy of immune checkpoint blockade (ICB) in cancer. The actin regulatory protein hMENA undergoes tissue-specific splicing, producing the epithelial hMENA
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Modugno et al. (2024) studied this question.
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