Rhodium-Catalyzed Enantio- and Regioselective Allylation of In-doles with gem-Difluorinated Cyclopropanes

The use of gem-difluorinated cyclopropanes (gem-DFCPs) as fluoroallyl surrogates under transition-metal catalysis has drawn considerable attention recently but such reac-tions are restricted to producing achiral or racemic mono-fluoroalkenes. Herein, we report the first enantioselective allylation of indoles with gem-DFCPs under rhodium catal-ysis. This reaction shows exceptional branched regioselec-tivity towards rhodium catalysis with gem-DFCPs, which provides an efficient route to enantioenriched fluoroal-lylated indoles with wide substrate scope and good func-tional group tolerance.