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The kinetic resolution of racemic secondary alcohols has been realized in an acylation reaction catalyzed by a supramolecular catalyst consisting of an enantiomerically enriched Cu-coordinated capsule and an achiral guest possessing a catalytic center. The enantioselective acylation proceeds at the exterior of a supramolecular catalyst. The cover picture represents the catalytic center of the supramolecular catalyst that accelerates the acylation of either enantiomer, resulting in the successful kinetic resolution of racemic secondary alcohols. More information can be found in the Research Article by T. Haino and co-workers (DOI: 10.1002/chem.202304244).
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Harada et al. (2024) studied this question.
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