Background: Buprenorphine is used for medication-assisted treatment of opioid dependence. Purpose: Monitoring of medication adherence involves testing of urine or oral fluid for the drug or its metabolite. Methods: Quantitative results using liquid chromatography tandem mass spectrometer testing defined the excretion pattern of the drug and its metabolites. Results: Frequency distribution curves of buprenorphine and norbuprenorphine describe the expected drug concentrations of patients on this medication. Conclusion: Urine and oral fluid drug testing can be used to monitor adherence in this population.
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Pesce et al. (2024) studied this question.
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