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October 9, 2025Frontiers in PharmacologyOpen Access

Anti-inflammatory effect of curcumin on neurological disorders: a narrative review

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Authors

BZBoyang ZhouBHBinbin Hu

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Overview

This narrative review highlights curcumin's anti-inflammatory role in neuroinflammation and neurodegeneration, suggesting therapeutic approaches.

Key Points

  • Curcumin suppresses neuroinflammation, contributing to potential treatment for neurological disorders.
  • It regulates key pathways like NF-κB and NLRP3 inflammasome, upregulating anti-inflammatory cytokines.
  • Microglial cells are vital in neuroinflammatory processes and the site of curcumin's action in the nervous system.
  • The review explores curcumin's multifaceted impact on neurodegeneration, underlining its clinical relevance.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68e7ba40ccde5f1021f64a5ahttps://doi.org/10.3389/fphar.2025.1658115
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Also Consider

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  1. 1The Neuroprotective Role of Curcumin: From Molecular Pathways to Clinical Translation—A Narrative Review2025 · 45 citations
  2. 2Neuroprotective Potential of Curcumin in Neurodegenerative Diseases: Clinical Insights Into Cellular and Molecular Signaling Pathways.2025 · 24 citations
  3. 3Regulation mechanism of curcumin mediated inflammatory pathway and its clinical application: a review2025 · 31 citations
  4. 4Immunoregulatory Effect of Curcumin on Experimental Autoimmune Encephalomyelitis (EAE), an Animal Model of Multiple Sclerosis (MS)2026
  5. 5Neuroprotective effect of curcumin is mainly mediated by blockade of microglial cell activation2007