How effective is the combination of ethacridine lactate and Foley catheter balloon dilation for second-trimester pregnancy termination after previous caesarean delivery? a retrospective, case-control study

Abstract Background: For pregnant women with uterine scars, the range of treatment options for second-trimester pregnancy termination is rather limited, and the risk of maternal complications is quite high. Research aim: we will investigate the safety and efficacy of the combination of ethacridine lactate and Foley catheter balloon dilation for second-trimester pregnancy termination after previous caesarean delivery. Methods: According to the inclusion criteria, 50 pregnant women with a history of cesarean section who chosed intra-amniotic injection of ethacridine lactate combined with Foley catheter balloon dilation were included in the study group. 93 cases who chosed intra-amniotic injection of ethacridine lactate were included in the control group. Results: Compared with the control group, the time from induction-to-abortion interval of the study group were shorter (1.38±0.67 days VS 1.71±0.73 days, P<0.05), but the blood loss in 24 h were more (348.80±184.86 ml VS 288.28±136.43 ml, P<0.05).There was no significant difference in the postpartum hemorrhageand the rate of retained placental tissuebetween the two groups (P>0.05) Conclusion: The combination of ethacridine lactate and Foley catheter balloon dilation for second-trimester pregnancy termination can shorten the induction-to-abortion interval, but it may increase blood loss in 24 h.