What is the clinical evidence from this study?

Study design: Other. Population: Cardiac aging. Intervention: Aging vs. Young and middle-aged mice. Primary outcome: Senescence-associated secretory phenotype (SASP) and its molecular drivers in non-cardiomyocytes.

What type of study is this?

This is a Meta-Analysis study (also classified as: Experimental Study).

October 9, 2025Circulation Research

Abstract Thu091: Unraveling the Role of the Senescence-Associated Secretory Phenotype in Cardiac Aging Through Meta-Analysis and Experimental Validation

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Key result

Single-cell dual-omics reveals widespread SASP across most non-cardiomyocytes during cardiac aging.

Population

Young, middle-aged, and elderly mice and non-cardiomyocytes/cardiomyocytes

Design

Preclinical

Authors

YSYiran SongUniversity of Minnesota HWHaofei WangHebei Medical University JLJiandong LiuPediatric / Congenital Cardiology

Discussion

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Implication

Single-cell dual-omics analysis reveals that the senescence-associated secretory phenotype is a prevalent feature of non-cardiomyocytes in the aging murine heart, identifying potential molecular drivers as therapeutic targets for age-related heart dysfunction.

Key Points

The study identifies the senescence-associated secretory phenotype as prevalent in non-cardiomyocytes during cardiac aging, which impacts heart function.
Through single-cell analysis, significant aging response heterogeneity among non-cardiomyocytes was documented across various age stages in mice.
The research employs dual-omics approaches to explore the interaction between non-cardiomyocytes and cardiomyocytes in relation to inflammatory and fibrotic processes.
Findings suggest that targeting key driver genes related to the senescence-associated secretory phenotype could lead to new therapies for age-related heart dysfunction.

Structured PICO

Population

Young, middle-aged, and elderly mice (in vivo model) and non-cardiomyocytes/cardiomyocytes (in vitro co-culture system)

Exposure

Single-cell RNA-seq and scATAC-seq profiling of non-cardiomyocytes; silencing of senescence-associated secretory phenotype (SASP) driver genes in a co-culture system

Outcome

Transcriptomic and epigenomic profiles of non-cardiomyocytes, SASP-related gene expression patterns, and effects of silencing driver genes on cardiomyocyte phenotypesurrogate

Cite This Study

Song et al. (2025) studied Cardiac aging. Aging vs. Young and middle-aged mice was evaluated on Senescence-associated secretory phenotype (SASP) and its molecular drivers in non-cardiomyocytes. Single-cell dual-omics analysis in murine hearts revealed that the senescence-associated secretory phenotype is prevalent in most non-cardiomyocyte cell types during cardiac aging.

synapsesocial.com/papers/68e80eb363e2e2f707877dcd https://doi.org/10.1161/res.137.suppl_1.thu091

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Abstract Thu091: Unraveling the Role of the Senescence-Associated Secretory Phenotype in Cardiac Aging Through Meta-Analysis and Experimental Validation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Abstract Thu091: Unraveling the Role of the Senescence-Associated Secretory Phenotype in Cardiac Aging Through Meta-Analysis and Experimental Validation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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