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Case report reveals that anakinra improves outcomes in severe purpura fulminans, showing vital anti-inflammatory effects.
Purpura fulminans (PF) is a rare, often fatal pediatric condition characterized by intravascular thrombosis and hemorrhagic infarction of the skin. A timely diagnosis and treatment are paramount to prevent the involvement of internal organs, causing disseminated intravascular coagulation and gangrene of the extremities. The management of PF requires a comprehensive approach, including the treatment of the underlying infection, anticoagulation, and anti‐inflammatory therapy. Herein we present the case of a child with severe PF successfully treated with anakinra, an anti‐IL1‐receptor monoclonal antibody.
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Zulian et al. (2025) studied this question.
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