Analysis reveals the significance of kinetic isotope effects in the benzidine rearrangement mechanism, suggesting insights into reaction pathways.
Kinetic isotope effects have become something of a lost art when it comes to exploring reaction mechanisms. But in their heyday they were absolutely critical for establishing the mechanism of the benzidine rearrangement. This classic mechanism proceeds via bisprotonation of diphenyl hydrazine, but what happens next was the crux.
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Henry S. Rzepa (2013) studied this question.
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