This analysis explores the enantioselectivity in the sharpless epoxidation reaction, highlighting conformational effects.
I return to this reaction one more time. Trying to explain why it is enantioselective for the epoxide product poses peculiar difficulties. Most of the substituents can adopt one of several conformations, and some exploration of this conformational space is needed.
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Henry S. Rzepa (2013) studied this question.
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