Reticular erythematous mucinosis: a systematic review of a controversial entity

Reticular erythematous mucinosis (REM) is a rare chronic dermatosis, predominantly affecting middle age women, characterized by net-like macules and patches on the chest and back. The etiology of REM is uncertain, though associations with environmental, hormonal, and autoimmune factors have been suggested. This systematic review of 62 studies, involving 129 patients, analyzes the clinical, histopathological, and therapeutic aspects of REM. Findings indicate consistent mucin deposition in the dermis, a predominant lymphocytic infiltrate, and a frequent association with comorbidities like thyroid disorders and autoimmune diseases. Antimalarial medications, particularly hydroxychloroquine, are highlighted as the most effective treatment, though the disease may relapse upon cessation. This review emphasizes REM as a distinct clinical entity and underscores the need for further research to refine diagnostic criteria and treatment protocols.