This research demonstrates the synthesis of new esters from vanillic acid, suggesting a pathway for effective chemotherapeutic agents.
Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is a dihydroxy benzoic acid derivative used as a flavoring agent. It is used in the synthesis of various active pharmaceutical ingredients such as Etamivan, Modecainide, Brovanexine, Vanitiolide, Vanyldisulfamide etc. In this paper, novel ester / hybrid derivative of vanillic acid was synthesized. This combinatorial synthesis of novel vanallic ester / hybrid derivative can be a useful approach to generate potent chemotherapeutic agents in developing new drug candidates.
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Gangan et al. (2025) studied this question.
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