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October 11, 2025Saudi Pharmaceutical JournalOpen Access

Acidifying agents impact erlotinib and gefitinib pharmacokinetic parameters and elevate liver enzymes in Wistar rats

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Authors

AAAmsha S. AlsegianiKing Saud UniversityAAAliyah AlmomenKing Saud UniversityMAMaria ArafahKing Saud Medical City

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Implication

This study demonstrates how acidifying agents alter pharmacokinetic parameters of erlotinib and gefitinib in Wistar rats, suggesting careful monitoring of drug interactions.

Key Points

  • Both erlotinib and gefitinib pharmacokinetic parameters were significantly altered by acidifying agents.
  • High doses of citric acid increased the Cmax of erlotinib by 103% and the area under the curve by 35%.
  • Significant liver enzyme elevations were observed in rats after two weeks of consuming acidifying agents.
  • Close monitoring is necessary when administering erlotinib and gefitinib with acidifying agents, given their impact on drug kinetics.

Cite This Study

Alsegiani et al. (2025) studied this question.

synapsesocial.com/papers/68e9b1b5ba7d64b6fc1320bbhttps://doi.org/10.1007/s44446-025-00032-4
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