Observational analysis shows tumor burden reduction with auranofin and cisplatin in models, indicating benefits for notch-dependent ovarian cancer.
Patient-derived tumor models used in this study. A, Clinical platinum sensitivity of the patients with HGSOC from whom the organoid models were derived. B, Western blot analysis of total cell lysates showing NOTCH3 and RBPJ protein levels in eight patient-derived models. GAPDH was used as the loading control.
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Lake et al. (2025) studied this question.
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