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October 12, 2025Open Access

Systems Pharmacology Model Predicts Zinc and Copper Can Be Repurposed as Endometriosis Therapies

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Authors

PGPablo Garcia-AceroFSF. SanzPSPatricia Sebastián-León

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Overview

Data-driven analyses find zinc and copper may improve endometriosis treatments, suggesting new therapeutic avenues.

Key Points

  • Repurposing zinc and copper shows promise, reducing endometriosis cell proliferation and migration effectively.
  • The study identified 16 candidate drugs, with zinc and copper having superior efficacy against endometriosis-related genes.
  • A systems pharmacology approach integrated protein interactions and approved drugs to enhance endometriosis therapy predictions.
  • Zinc and copper emerged as safe options with minimal side effects, calling for further clinical trials to validate effectiveness.

Cite This Study

Garcia-Acero et al. (2025) studied this question.

synapsesocial.com/papers/68ebe3d6becc64ad52fdaf15https://doi.org/10.1101/2025.10.06.25337149
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