October 12, 2025Open Access

The spatial landscape of infectious mononucleosis tonsils

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This multiomic atlas uncovers EBV's rare epithelial infection and its implications for immune microenvironments.

The study reveals a complex interplay of EBV infection in tonsils, highlighting unexpected epithelial cell involvement.
Analysis detected rare EBV-infected epithelial cells, challenging previous assumptions about infection site exclusivity.
Cellular investigation shows the LMP1 protein forms an immunosuppressive niche with increased macrophage presence.
Findings suggest a dynamic relationship between EBV latency and the immune environment, shaping viral persistence.

Leahy et al. (2025) studied this question.

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