This study demonstrates improved predictive accuracy in drug kinetics using PBPK modelling for MAP, highlighting key challenges in evaluation and translation.
Key Points
The optimised PBPK model shows robust predictive performance for diverse drug molecules including loratadine and chlorpheniramine maleate.
Validation was performed through in vitro testing using porcine skin and in vivo studies in pigs for itraconazole microarray patches.
This modelling approach addresses challenges like experimental variability and complex study designs affecting preclinical evaluation.
Incorporating microneedle geometry and drug release kinetics enhances the applicability of PBPK models in drug delivery systems.