This study finds associations of anti-AT1R and anti-ETAR antibodies with endothelial dysfunction in systemic sclerosis patients, suggesting potential biomarkers.
Background Aims of this study were to evaluate the serum level of autoantibodies against G-protein-coupled receptors for Angiotensin II type 1 (anti-AT1R) and endothelin receptor type A (anti-ETAR) in systemic sclerosis (SSc) patients and healthy controls (HC) and to evaluate the associations of these antibodies with microvascular complication of SSc, such as digital ulcers (DUs), subclinical renal vasculopathy and early pulmonary vasculopathy.
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Pellicano et al. (2025) studied this question.
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