Observational analysis demonstrates that indirubin regulates M1/M2 polarization and inhibits ferroptosis in cultured THP-1 cells, suggesting potential benefits for ulcerative colitis treatment.
Context Macrophages play a critical role in the pathogenesis of ulcerative colitis (UC). Indirubin (IDR), a natural ligand of the aryl hydrocarbon receptor (AhR), has been shown to ameliorate DSS-induced colitis in our previous study (Liu Z et al.).
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Huang et al. (2025) studied this question.
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