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This is a Experimental Study study.

Optimizing CAR-T Therapy through CRISPR technology

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This analysis demonstrates improved efficacy of CAR-T therapy using CRISPR technology, highlighting challenges in gene targeting.

CRISPR technology enhances car-t therapy's precision and safety by creating universal car-t cells, reducing immune rejection.
Targeting genes like TRAC and B2M enables the development of adaptable car-t cells, overcoming limitations in existing treatments.
Controllable cas9 systems can regulate car-t activity, lowering side effects such as cytokine release syndrome.
Despite advancements, challenges like off-target effects and delivery efficiency must be addressed for solid tumor treatment.

Yuchen Liu (2025) studied this question.

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